The two halves of the film don’t really fit together: contemporary evil corporation manipulating duped experimental subjects, and Renaissance intrigue, murder, and mayhem. Welded together with the crude device of a conspiracy plot more at home in a Dan Brown novel than in a sane mind: The Catholic Church seeks to enslave mankind with evil intent. Presumably giving all the Anglo Protestants in the USA justification to arm themselves to the teeth, form militias, and destroy civilisation to save it from destruction by the Catholics. A fine piece of contemporary American logic.
Worse, from my perspective: there is a substantial portion of dialogue in Spanish, forcing me to turn to sub-titles, which I have always thought of as destroyers of a film. Both for distracting from the visuals, and for usually being the work of illiterate gremlins guessing at original meaning rather than translating it.